7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Base Information

Chemical Name:7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
CAS No.:118314-19-5
Molecular Formula:C₁₄H₁₉N₅O₃S
Molecular Weight:337.403
Hs Code.:

Synonyms:7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of 7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Technology Process of 7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

There total 8 articles about 7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 146449-38-9
7-Chloro-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

: 118314-19-5
7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: With ammonium hydroxide; In ethanol; for 5.5h; Ambient temperature;
DOI:10.1248/cpb.40.2391

Reference yield:

: 1124-63-6
3-cyclohexylpropan-1-ol

: 118314-19-5
7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

2: 96.2 percent / dimethylsulfoxide

3: 73 percent / CF₃COOH

4: 59.6 percent / heptane / 2 h / 140 - 150 °C

5: 78.1 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

6: 99 percent / tripropylamine, POCl₃ / 3 h / 80 - 85 °C

7: 84.8 percent / concd. NH₄OH / ethanol / 5.5 h / Ambient temperature

With tri-n-propylamine; ammonium hydroxide; nitric acid; phosphorus tribromide; acetic acid; trifluoroacetic acid; trichlorophosphate; In diethyl ether; ethanol; n-heptane; dimethyl sulfoxide;
DOI:10.1248/cpb.40.2391

Reference yield:

: 4441-66-1
3-cyclohexylpropionitrile

: 118314-19-5
7-Amino-2-(3-cyclohexyl-propyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / CF₃COOH

2: 59.6 percent / heptane / 2 h / 140 - 150 °C

3: 78.1 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

4: 99 percent / tripropylamine, POCl₃ / 3 h / 80 - 85 °C

5: 84.8 percent / concd. NH₄OH / ethanol / 5.5 h / Ambient temperature

With tri-n-propylamine; ammonium hydroxide; nitric acid; acetic acid; trifluoroacetic acid; trichlorophosphate; In ethanol; n-heptane;
DOI:10.1248/cpb.40.2391