8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Base Information

Chemical Name:8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate
CAS No.:1616830-85-3
Molecular Formula:C₂HF₃O₂*C₁₆H₁₄N₂O₄S
Molecular Weight:444.388
Hs Code.:

Synonyms:8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Suppliers and Price of 8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

There total 7 articles about 8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1616830-86-4
6-(2-(methylsulfonylmethyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 76-05-1
trifluoroacetic acid

: 1616830-85-3
8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1616828-60-4
6-bromo-8-(2-trimethylsilanyl-ethoxymethoxy)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-quinazolin-4-one

: 1616830-85-3
8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 15 h / 90 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 25 °C

4: dichloromethane / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1215634-37-9
4-bromo-2-carboxy-6-methoxybenzenamine hydrobromide

: 1616830-85-3
8-hydroxy-6-(2-(methylsulfonylmethyl)phenyl)quinazolin-4(3H)-one 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 12 h / 150 °C

2: hydrogen bromide; water / acetic acid / 96 h / 130 °C

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 80 °C / Cooling with ice

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 15 h / 90 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 25 °C

7: dichloromethane / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; hydrogen bromide; potassium acetate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;