METHYL 6-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 6-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLATE
• CAS No.: 176641-35-3
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Hs Code.: 2933499090
• Mol file: 176641-35-3.mol

Synonyms:2-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-6-methoxy-, methyl ester

Chemical Property of METHYL 6-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 361.6°Cat760mmHg
• Flash Point: 172.5°C
• PSA: 47.56000
• Density: 1.14g/cm³
• LogP: 1.73290

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl6-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLATE

There total 2 articles about METHYL 6-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 6-methoxyquinoline-2-carboxylate (176641-33-1) → methyl 6-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylate (176641-35-3)

Guidance literature:

With tris(pentafluorophenyl)borate; hydrogen; In toluene; at 110 ℃; for 12h; under 30402 Torr; Autoclave; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.02.057

Reference yield:

hydrochloric ethanol + methyl 6-methoxyquinoline-2-carboxylate (176641-33-1) → methyl 6-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylate (176641-35-3)

Guidance literature:

With ammonium hydroxide; In methanol; hydrated platinum oxide; di-isopropyl ether; Petroleum ether;

upstream raw materials:

methyl 6-methoxyquinoline-2-carboxylate

Refernces

• 1、 Zhao, Zi-Biao,Wang, Jie,Zhu, Zhou-Hao,Chen, Mu-Wang,Zhou, Yong-Gui. "Enantioselective Synthesis of 2-Functionalized Tetrahydroquinolines through Biomimetic Reduction". supporting information. p. 9112 - 9117. Retrieved 2021/11/24.