7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine
• CAS No.: 109774-08-5
• Molecular Formula: C₂₁H₁₅ClFN₃
• Molecular Weight: 363.822

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine

Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine

There total 3 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide (109774-03-0) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine (109774-08-5)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1002/jhet.5570230509

Reference yield:

α-picoline (109-06-8) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine (109774-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) -50 deg C, tetrahydrofuran 2) warming, 45 min.

2: 79 percent / PCl₃ / CH₂Cl₂; tetrahydrofuran / 0.25 h / Ambient temperature

With lithium diisopropyl amide; phosphorus trichloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570230509

Reference yield:

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine (109774-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) -50 deg C, tetrahydrofuran 2) warming, 45 min.

2: 79 percent / PCl₃ / CH₂Cl₂; tetrahydrofuran / 0.25 h / Ambient temperature

With lithium diisopropyl amide; phosphorus trichloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570230509

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

α-picoline

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

Downstream raw materials:

9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-4-(2-pyridyl)-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine

<7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl>-2-pyridylmethanone O-methyloxime

<7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-yl>-2-pyridylmethanone O-methyloxime

8-chloro-6-(2-fluorophenyl)-1-methyl-3-(2-pyridyl)-4H-imidazo<1,5-a><1,4>-benzodiazepine

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