5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide

Base Information

• Chemical Name: 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide
• CAS No.: 1330738-58-3
• Molecular Formula: C₃₀H₃₂N₄O₅
• Molecular Weight: 528.608
• Mol file: 1330738-58-3.mol

Synonyms:5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide

Chemical Property of 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide

There total 2 articles about 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-cyano-N-ethylisoxazole-3-carboxamide (1330736-56-5) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide (1330738-58-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; for 16h; Reflux;

Reference yield:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide (747414-22-8) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide (1330738-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / Reflux

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 16 h / Reflux

With hydroxylamine hydrochloride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; acetonitrile;

Reference yield: 73.0%

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide (1330738-58-3) + trimethyl orthoformate (149-73-5) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide (1330738-97-0)

Guidance literature:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(N'-hydroxycarbamimidoyl)isoxazole-3-carboxamide; trimethyl orthoformate; With p-toluenesulfonic acid monohydrate; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-cyano-N-ethylisoxazole-3-carboxamide

Downstream raw materials:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(5-hydroxy-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(5-mercapto-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethyl-4-(1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide