Technology Process of benzyl 3-chloro-4-[(2,4,4-trimethylpentan-2-yl)amino]-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
There total 6 articles about benzyl 3-chloro-4-[(2,4,4-trimethylpentan-2-yl)amino]-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h
3.1: N-chloro-succinimide / dichloromethane / 5 h / 20 °C
4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C
6.1: chloroform / 0.25 h
6.2: 1 h / 0 - 20 °C
With
N-chloro-succinimide; hydrogen; dimethyl amine; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid / sulfuric acid / 2 h / 0 - 100 °C
2.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h
4.1: N-chloro-succinimide / dichloromethane / 5 h / 20 °C
5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C
7.1: chloroform / 0.25 h
7.2: 1 h / 0 - 20 °C
With
N-chloro-succinimide; hydrogen; nitric acid; dimethyl amine; triethylamine; 3-chloro-benzenecarboperoxoic acid;
sulfuric acid; palladium 10% on activated carbon;
In
methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h
2.1: N-chloro-succinimide / dichloromethane / 5 h / 20 °C
3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C
5.1: chloroform / 0.25 h
5.2: 1 h / 0 - 20 °C
With
N-chloro-succinimide; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; chloroform;
