3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Base Information

• Chemical Name: 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one
• CAS No.: 1613152-68-3
• Molecular Formula: C₂₈H₂₈N₂O₃
• Molecular Weight: 440.542

Synonyms:3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Chemical Property of 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

There total 5 articles about 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminophenylacetic acid (1197-55-3) → 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

5: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Perkin Coumarin Rearrangement;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

(2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8) → 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

5: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Perkin Coumarin Rearrangement;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

N-(4-(4-(4-methoxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide (1613152-62-7) → 3-(4-aminophenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 1 h

2: potassium carbonate / acetone / Reflux

3: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

4: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;

DOI:10.1016/j.bmcl.2014.04.106

upstream raw materials:

4-aminophenylacetic acid

(2-hydroxyphenyl)(4-methoxyphenyl)methanone

N-(4-(4-(4-methoxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

N-(4-(4-(4-hydroxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

Downstream raw materials:

N¹,N³-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)malonamide

N¹,N⁶-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)adipamide

N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

N¹,N³-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)isophthalamide

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