N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• CAS No.: 1202389-41-0
• Molecular Formula: C₁₆H₁₆BrClN₆
• Molecular Weight: 407.7

Synonyms:N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Chemical Property of N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

There total 1 articles about N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine (543712-81-8) + 4-bromo-2,5-dimethylaniline (30273-40-6) → N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-41-0)

Guidance literature:

2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine; 4-bromo-2,5-dimethylaniline; With hydrogenchloride; In water; isopropyl alcohol; at 130 ℃; for 1.66667h; microwave;

With sodium hydrogencarbonate; In water; ethyl acetate; isopropyl alcohol;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-41-0) → N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-42-1)

Guidance literature:

3,4-dihydro-2H-pyran; N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

potassium (morpholin-4-yl)methyltrifluoroborate + N2-(4-bromo-2,5-dimethylphenyl)-5-chloro-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202389-41-0) → 5-chloro-N2-(2,5-dimethyl-4-(morpholinomethyl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (1202388-30-4)

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; water; at 160 ℃; for 1h; Inert atmosphere; Sealed;

upstream raw materials:

2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

4-bromo-2,5-dimethylaniline

Downstream raw materials:

N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-chloro-N₂-(2,5-dimethyl-4-(morpholinomethyl)phenyl)-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone

1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

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