N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

Base Information

Chemical Name:N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide
CAS No.:1246612-52-1
Molecular Formula:C₂₅H₂₃ClF₃N₃O₂
Molecular Weight:489.925
Hs Code.:

Synonyms:N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

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Chemical Property of N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

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Technology Process of N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

There total 5 articles about N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1246612-51-0
1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

: 407-25-0
trifluoroacetic anhydride

: 1246612-52-1
N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 106-47-8
4-chloro-aniline

: 1246612-52-1
N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride / dichloromethane; toluene / 3 h / Reflux

1.2: 0.5 h / 20 °C

2.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; titanium tetrachloride; In dichloromethane; toluene;

Reference yield:

: 488149-34-4
2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide

: 1246612-52-1
N-(4-chlorophenyl)-2,2,2-trifluoro-N-[1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-4-yl]acetoamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -78 - 20 °C

1.2: 70 °C

2.1: titanium tetrachloride / dichloromethane; toluene / 3 h / Reflux

2.2: 0.5 h / 20 °C

3.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene;