1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

Base Information

Chemical Name:1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine
CAS No.:1246612-51-0
Molecular Formula:C₂₃H₂₄ClN₃O
Molecular Weight:393.916
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

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Chemical Property of 1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

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Technology Process of 1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

There total 3 articles about 1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1246612-49-6
2,3-dihydro-1-(4-methoxybenzyl)-2-methyl-1,8-naphthyridin-4(1H)-one

: 106-47-8
4-chloro-aniline

: 1246612-51-0
1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

Guidance literature:: 2,3-dihydro-1-(4-methoxybenzyl)-2-methyl-1,8-naphthyridin-4(1H)-one; 4-chloro-aniline; With titanium tetrachloride; In dichloromethane; toluene; for 3h; Reflux;

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 488149-34-4
2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide

: 1246612-51-0
1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 - 20 °C

1.2: 70 °C

2.1: titanium tetrachloride / dichloromethane; toluene / 3 h / Reflux

2.2: 0.5 h / 20 °C

With titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 1246612-51-0
1-(4-methoxybenzyl)-4-[(4-chlorophenyl)amino]-2-methyl-3,4-dihydro-2H-[1,8]-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / benzene / 3 h / Reflux

1.2: 20 °C / Cooling with ice

2.1: tetrahydrofuran / -78 - 20 °C

2.2: 70 °C

3.1: titanium tetrachloride / dichloromethane; toluene / 3 h / Reflux

3.2: 0.5 h / 20 °C

With thionyl chloride; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; benzene;