2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

Base Information

• Chemical Name: 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
• CAS No.: 1320288-52-5
• Molecular Formula: C₃₅H₅₇N₇O₂
• Molecular Weight: 607.883
• Mol file: 1320288-52-5.mol

Synonyms:2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

Chemical Property of 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine

There total 9 articles about 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chloro-N-(1-isopropylpiperidin-4-yl)-6-methoxyl-7-(3-(pyrrolidin-1-yl)propoxyl)quinazolin-4-amine (1350752-07-6) + 1-cyclohexyl-1,4-diazepane (59039-67-7) → 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine (1320288-52-5)

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 160 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jm200903z

Reference yield:

2,4-dichloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (1320288-30-9) → 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine (1320288-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: trifluoroacetic acid / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jm200903z

Reference yield:

C17H25N3O5 (1320288-27-4) → 2-(4-cyclohexyl-1,4-diazepan-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine (1320288-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1: water; sodium hydroxide / methanol / 3 h / Reflux

2: N,N-diethylaniline; trichlorophosphate / 7 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: trifluoroacetic acid / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; isopropyl alcohol;

DOI:10.1021/jm200903z

upstream raw materials:

2,4-dichloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

2-chloro-N-(1-isopropylpiperidin-4-yl)-6-methoxyl-7-(3-(pyrrolidin-1-yl)propoxyl)quinazolin-4-amine

1-cyclohexyl-1,4-diazepane

methyl 5-methoxy-2-nitro-4-[3-(pyrrolidin-1-yl)propoxy]benzoate