(4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate

Base Information

• Chemical Name: (4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate
• CAS No.: 1045814-79-6
• Molecular Formula: C₂₈H₂₇NO₅
• Molecular Weight: 457.526

Synonyms:(4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate

Chemical Property of (4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate

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Technology Process of (4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate

There total 1 articles about (4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

benzyl (S)-5-methoxy-3-oxo-2,3,9,9a-tetrahydro-1H-indeno[2,1-b]pyridine-1-carboxylate (1045814-75-2) + (3-methoxyphenyl)magnesium bromide (36282-40-3) → (4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate (1045814-79-6)

Guidance literature:

(3-methoxyphenyl)magnesium bromide; With copper(l) iodide; In tetrahydrofuran; at -78 - 0 ℃; for 2.41667h; Inert atmosphere;

benzyl (S)-5-methoxy-3-oxo-2,3,9,9a-tetrahydro-1H-indeno[2,1-b]pyridine-1-carboxylate; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

DOI:10.1039/b805295f

Reference yield: 94.0%

(4aS,9aS)-benzyl-5-methoxy-4a-(3-methoxyphenyl)-3-oxo-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-1-carboxylate (1045814-79-6) → (4aS,9aS)-5-methoxy-4a-(3-methoxyphenyl)-4,4a,9,9a-tetrahydro-1H-indeno[2,1-b]-pyridin-3(2H)-one (1045814-84-3)

Guidance literature:

With 10% Pd/C; hydrogen; In methanol; for 0.333333h; under 760.051 Torr;

DOI:10.1039/b805295f

upstream raw materials:

benzyl (S)-5-methoxy-3-oxo-2,3,9,9a-tetrahydro-1H-indeno[2,1-b]pyridine-1-carboxylate

(3-methoxyphenyl)magnesium bromide

Downstream raw materials:

(4aS,9aS)-5-methoxy-4a-(3-methoxyphenyl)-4,4a,9,9a-tetrahydro-1H-indeno[2,1-b]-pyridin-3(2H)-one

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