Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Base Information

Chemical Name:Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-
CAS No.:176379-12-7
Molecular Formula:C₂₂H₂₀N₄O₇
Molecular Weight:452.423
Hs Code.:
Mol file:176379-12-7.mol

Synonyms:Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Suppliers and Price of Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

Chemical Property:

PSA：155.21000
LogP:2.18650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-

There total 5 articles about Benzamide, 3,4-bis(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.6%

: 50786-93-1
5,6-diamino-3-methyl-1-phenyluracil

: 58534-64-8
3,4-Diacetoxy-benzoesaeure

: 176379-12-7
acetic acid 2-acetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: With triethylamine; Diphenylphosphinic chloride; In dichloromethane; at 0 ℃;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 99-50-3
3,4-Dihydroxybenzoic acid

: 176379-12-7
acetic acid 2-acetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; ethyl acetate

2: 57.6 percent / Et₃N; DPP-Cl / CH₂Cl₂ / 0 °C

With triethylamine; Diphenylphosphinic chloride; In pyridine; dichloromethane; ethyl acetate; 1: Acetylation / 2: Condensation;
DOI:10.1016/S0968-0896(00)00126-7

Reference yield:

: 42212-19-1
6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione

: 176379-12-7
acetic acid 2-acetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaNO₂; 5N HCl

1.2: H₂ / Pd-C / ethanol / Heating

2.1: 57.6 percent / Et₃N; DPP-Cl / CH₂Cl₂ / 0 °C

With hydrogenchloride; triethylamine; sodium nitrite; Diphenylphosphinic chloride; In dichloromethane; 1.1: Nitrosation / 1.2: Catalytic hydrogenation / 2.1: Condensation;
DOI:10.1016/S0968-0896(00)00126-7