2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

Base Information

Chemical Name:2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid
CAS No.:1429384-16-6
Molecular Formula:C₂₂H₂₃Cl₂NO₄
Molecular Weight:436.335
Hs Code.:

Synonyms:2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

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Chemical Property of 2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

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Technology Process of 2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

There total 4 articles about 2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429384-17-7
tert-butyl 2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetate

: 1429384-16-6
2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1429384-05-3
(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

: 1429384-16-6
2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 14 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1429384-06-4
tert-butyl 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetate

: 1429384-16-6
2-((2S,5R,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 14 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;