(2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine

Base Information

• Chemical Name: (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine
• CAS No.: 1190071-25-0
• Molecular Formula: C₂₄H₃₀N₄
• Molecular Weight: 374.529
• Mol file: 1190071-25-0.mol

Synonyms:(2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine

Chemical Property of (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine

There total 4 articles about (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-(3,5-dimethylpyrazol-1-yl)-2-acetylpyridine (1190071-17-0) + 2,6-diisopropylbenzenamine (24544-04-5) → (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine (1190071-25-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 48h; Reflux; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.jorganchem.2009.05.028

Reference yield:

ethyl 6-(3,5-dimethylpyrazol-1-yl)pyridine-2-carboxylate (1449292-68-5) → (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine (1190071-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium / ethanol; ethyl acetate / 5 h / Reflux

1.2: 4 h / Reflux

2.1: acetic acid / methanol / Reflux

With sodium; acetic acid; In methanol; ethanol; ethyl acetate;

DOI:10.1016/j.apcata.2013.04.026

Reference yield:

3,5-dimethyl-1H-pyrazole (67-51-6) → (2,6-diisopropylphenyl)-{1-[6-(3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl]ethylidene} amine (1190071-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 1,4-dioxane / Inert atmosphere; Reflux

2.1: sodium / ethanol; ethyl acetate / 5 h / Reflux

2.2: 4 h / Reflux

3.1: acetic acid / methanol / Reflux

With potassium tert-butylate; sodium; acetic acid; In 1,4-dioxane; methanol; ethanol; ethyl acetate;

DOI:10.1016/j.apcata.2013.04.026

upstream raw materials:

6-(3,5-dimethylpyrazol-1-yl)-2-acetylpyridine

2,6-diisopropylbenzenamine

6-bromopyridine-2-carboxylic acid ethyl ester

3,5-dimethyl-1H-pyrazole

Downstream raw materials:

[NiCl₂((2,6-diisopropylphenyl)-(1-(6-(3,5-dimethylpyrazol-1-yl)pyridin-2-yl)ethylidene) amine)]*H₂O

2-[1-(2,6-diisopropylphenylimino)ethyl]-6-(3,5-dimethylpyrazol-1-yl)pyridine cobaltdichloride