N-(6-methoxyquinolin-8-yl)butane-1,4-diamine

Base Information

• Chemical Name: N-(6-methoxyquinolin-8-yl)butane-1,4-diamine
• CAS No.: 5464-81-3
• Molecular Formula: C₁₄H₁₉N₃O
• Molecular Weight: 245.324
• Hs Code.: 2933499090
• Mol file: 5464-81-3.mol

Synonyms:1,4-Butanediamine,N-(6-methoxy-8-quinolinyl)- (9CI); Quinoline,8-[(4-aminobutyl)amino]-6-methoxy- (7CI,8CI); 8-[(4-Aminobutyl)amino]-6-methoxyquinoline;NSC 28776

Chemical Property of N-(6-methoxyquinolin-8-yl)butane-1,4-diamine

Chemical Property:

• Vapor Pressure: 3.27E-08mmHg at 25°C
• Boiling Point: 447.8°Cat760mmHg
• PKA: 10.38±0.10(Predicted)
• Flash Point: 224.6°C
• PSA: 60.17000
• Density: 1.149g/cm³
• LogP: 3.16750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(6-methoxyquinolin-8-yl)butane-1,4-diamine

There total 6 articles about N-(6-methoxyquinolin-8-yl)butane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(6-methoxyquinolin-8-ylamino)butanenitrile (855336-72-0) → JM1-156b (5464-81-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(99)00393-5

Reference yield:

N-[4-(6-methoxy-[8]quinolylamino)-butyl]-phthalimide (438621-49-9) → JM1-156b (5464-81-3)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01170a050 DOI:10.1039/jr9340001524

Reference yield:

6-methoxy-8-nitroquinoline (85-81-4) → JM1-156b (5464-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Raney-Ni / 1 h / 20 °C / 2585.74 Torr

2: Et₃N / 6 h / 150 °C

3: H₂NNH₂*H₂O / ethanol / 3 h / Heating

With hydrogen; hydrazine hydrate; triethylamine; nickel; In ethanol;

DOI:10.1016/S0960-894X(99)00393-5

upstream raw materials:

N-[4-(6-methoxy-[8]quinolylamino)-butyl]-phthalimide

4-(6-methoxyquinolin-8-ylamino)butanenitrile

6-methoxyquinolin-8-amine

6-methoxy-8-nitroquinoline

Downstream raw materials:

NSC14710

Refernces

• 1、 -. "AMINOQUINOLINE DERIVED HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE". Page/Page column 47-48. . Retrieved 2010/04/28.