(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

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Chemical Name:(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate
CAS No.:1421277-03-3
Molecular Formula:C₁₅H₁₇NO₃S
Molecular Weight:291.371
Hs Code.:

Synonyms:(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

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Chemical Property of (S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

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Technology Process of (S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

There total 3 articles about (S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 70-11-1
α-bromoacetophenone

: 80442-95-1
ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate

: 1421277-03-3
(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: With sodium carbonate; In dichloromethane; for 2.5h; Sonication;
DOI:10.1039/c2ra22033d

Reference yield: 84.0%

: 3282-32-4
2-diazo-acetophenone

: 80442-95-1
ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate

: 1421277-03-3
(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: With Grubbs catalyst first generation; In benzene; at 20 ℃; for 0.75h; Inert atmosphere; Sealed tube;
DOI:10.1021/jo5011312

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1421277-03-3
(S)-ethyl 5-((2-oxo-2-phenylethyl)thio)-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N'-ditosylhydrazine / tetrahydrofuran / 0.33 h / Cooling with ice

2: Grubbs catalyst first generation / benzene / 0.75 h / 20 °C / Inert atmosphere; Sealed tube

With Grubbs catalyst first generation; N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; benzene;
DOI:10.1021/jo5011312