6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1280218-25-8
Molecular Formula:C₁₆H₁₃F₂N₃O₃S
Molecular Weight:365.36
Hs Code.:

Synonyms:6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 5 articles about 6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1280218-24-7
6-(2,4-difluorobenzyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1280218-25-8
6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm101423y

Reference yield:

: 17759-30-7
(4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

: 1280218-25-8
6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / dichloromethane / 24 h

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 120 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With manganese(IV) oxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/jm101423y

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 1280218-25-8
6-(2,4-difluorobenzyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; dichloromethane / 0.5 h / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 5 °C

3: manganese(IV) oxide / dichloromethane / 24 h

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 120 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;
DOI:10.1021/jm101423y