tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate

Base Information

• Chemical Name: tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate
• CAS No.: 1207187-94-7
• Molecular Formula: C₂₂H₂₉N₃O₆
• Molecular Weight: 431.489
• Mol file: 1207187-94-7.mol

Synonyms:tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate

Chemical Property of tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate

There total 1 articles about tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) + 4-isopropoxy-2-phenylmethanesulfonyl-pyrimidine (497944-66-8) → tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate (1207187-94-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2009.11.077

Reference yield:

tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate (1207187-94-7) → C21H27N3O6

Guidance literature:

tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

With acetic acid; In tetrahydrofuran; methanol; water; pH=4;

DOI:10.1016/j.tet.2009.11.077

Reference yield:

tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)ethylcarbamate (1207187-94-7) → C16H19N3O4

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / dichloromethane; methanol; water / 25 °C

2: trifluoroacetic acid / dichloromethane / 0 - 25 °C

With lithium hydroxide monohydrate; trifluoroacetic acid; In methanol; dichloromethane; water;

DOI:10.1039/c4ob02235a

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

4-isopropoxy-2-phenylmethanesulfonyl-pyrimidine

Downstream raw materials:

(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid