(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

Base Information

Chemical Name:(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid
CAS No.:1207188-05-3
Molecular Formula:C₃₁H₂₉N₃O₆
Molecular Weight:539.588
Hs Code.:

Synonyms:

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Chemical Property of (S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

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Technology Process of (S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

There total 6 articles about (S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₉N₃O₄

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1207188-05-3
(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 25 ℃;
DOI:10.1039/c4ob02235a

Reference yield:

: (x)C₂HF₃O₂*C₁₆H₁₉N₃O₄

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1207188-05-3
(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

Guidance literature:: (x)C₂HF₃O₂*C₁₆H₁₉N₃O₄; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; pH=7;

With hydrogenchloride; In water; pH=1 - 2;
DOI:10.1016/j.tet.2009.11.077

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1207188-05-3
(S)-Nα-Fmoc-3-(4-(4-isopropoxypyrimidin-2-yloxy)phenyl)-2-aminopropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: lithium hydroxide monohydrate / dichloromethane; methanol; water / 25 °C

3: trifluoroacetic acid / dichloromethane / 0 - 25 °C

4: sodium hydrogencarbonate / 1,4-dioxane; water / 25 °C

With lithium hydroxide monohydrate; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c4ob02235a