5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole
CAS No.:719282-63-0
Molecular Formula:C₂₄H₃₆N₄O₂S
Molecular Weight:444.641
Hs Code.:

Synonyms:5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

There total 12 articles about 5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 719282-62-9
(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentan-1-ol

: 719282-63-0
5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

Guidance literature:: (R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentan-1-ol; With p-toluenesulfonyl chloride; In triethylamine;

1-Phenyl-1H-tetrazole-5-thiol; With potassium tert-butylate; Further stages.;
DOI:10.1016/j.tetlet.2004.03.169

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 719282-63-0
5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: CSA

1.2: TBAF

1.3: pyridine

2.1: K₂CO₃ / methanol / 56 °C

3.1: 64 percent / SO₃*Py; DMSO / triethylamine

4.1: 85 percent / LHMDS

5.1: 92 percent / H₂ / Pd(OH)2/C

6.1: 100 percent / TBAF

7.1: TsCl / triethylamine

7.2: 88 percent / t-BuOK

With pyridine-SO₃ complex; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dimethyl sulfoxide; p-toluenesulfonyl chloride; lithium hexamethyldisilazane; palladium dihydroxide; In methanol; triethylamine;
DOI:10.1016/j.tetlet.2004.03.169

Reference yield:

: 130710-56-4
(S)-3-<(R)-2-ethyl-1-oxo-4-penten-1-yl>-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 719282-63-0
5-[(R)-2-Ethyl-5-((R)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-pentylsulfanyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: LiBH₄

1.2: 73 percent / MS 4A; imidazole

2.1: OsO₄; NMO; NaIO₄

2.2: NaBH₄

3.1: 75 percent / n-Bu₃P; DIAD

4.1: 100 percent / (NH₄)6Mo₇O₂₄*4H₂O; H₂O₂

5.1: 85 percent / LHMDS

6.1: 92 percent / H₂ / Pd(OH)2/C

7.1: 100 percent / TBAF

8.1: TsCl / triethylamine

8.2: 88 percent / t-BuOK

With ammonium heptamolybdate; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; tributylphosphine; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; p-toluenesulfonyl chloride; lithium hexamethyldisilazane; palladium dihydroxide; In triethylamine; 2.1: Lemieux-Johnson oxidation;
DOI:10.1016/j.tetlet.2004.03.169