biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

Base Information

Chemical Name:biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone
CAS No.:1332455-28-3
Molecular Formula:C₂₈H₃₂N₄O₂
Molecular Weight:456.588
Hs Code.:

Synonyms:biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

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Chemical Property of biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

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Technology Process of biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

There total 5 articles about biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332455-46-5
C₁₅H₂₄N₄O

: 92-92-2
biphenyl-4-carboxylic acid

: 1332455-28-3
biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 18 - 25 ℃;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332455-28-3
biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 3 h / Reflux

2: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Reflux

3: ammonium formate / palladium(II) hydroxide / methanol / 3 h / Reflux

4: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 - 25 °C

With ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 914612-23-0
6-benzyl-4-chloro-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine

: 1332455-28-3
biphenyl-4-yl{4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}methanone

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Reflux

2: ammonium formate / palladium(II) hydroxide / methanol / 3 h / Reflux

3: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 - 25 °C

With ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;