6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
• CAS No.: 109229-22-3
• Molecular Formula: C14H15N3O
• Molecular Weight: 241.293
• Mol file: 109229-22-3.mol

Synonyms:Pyrido[4,3-d]pyrimidin-4(1H)-one,5,6,7,8-tetrahydro-6-(phenylmethyl)- (9CI);6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;

Chemical Property of 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

Chemical Property:

• Melting Point: 165-166.5 °C(Solv: acetone (67-64-1))
• Refractive Index: 1.662
• Boiling Point: 406.5±55.0 °C(Predicted)
• PKA: 6.65±0.20(Predicted)
• Density: 1.27 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one is used in the discovery/optimization of quinazolinones as new P2X3 receptor antagonists.

Technology Process of 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

There total 8 articles about 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

formamidine hydrochloride (6313-33-3) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (109229-22-3)

Guidance literature:

With sodium methylate; In methanol; at 85 ℃;

Reference yield: 61.4%

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (109229-22-3)

Guidance literature:

formamidine acetic acid; ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride; With sodium methylate; In methanol; at 85 ℃; for 16h; in sealed vessel;

With sodium hydroxide; In water; at 0 ℃;

With acetic acid; In water; pH=7;

Reference yield: 55.0%

C9H14O3NC6H5 (41276-30-6) + formamidine acetic acid (3473-63-0) → 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (109229-22-3)

Guidance literature:

With ethanol; sodium ethanolate; Reflux;

upstream raw materials:

C₉H₁₄O₃NC₆H₅

formamidine hydrochloride

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

1-benzyl-4-aminotetrahydropyridine-3-carboxylic acid methyl ester

Downstream raw materials:

6-[3-(1,3-benzothiazol-2-yl)propanoyl]-4-(4-fluorobenzyl)-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine

6-benzyl-4-bromo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

6-benzyl-4-(4-fluorobenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

tert-butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

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