N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

Base Information

Chemical Name:N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide
CAS No.:1163144-41-9
Molecular Formula:C₂₀H₂₄N₄O₂
Molecular Weight:352.436
Hs Code.:

Synonyms:N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

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Technology Process of N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

There total 1 articles about N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1163144-36-2
N,N-diethyl-2-(2-(4-methoxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

: 1163144-41-9
N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

Guidance literature:: N,N-diethyl-2-(2-(4-methoxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 17h;

With methanol; In dichloromethane; Product distribution / selectivity;

Reference yield: 58.0%

: 1163144-41-9
N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

: 383-50-6
2-fluoroethyl tosylate

: 1163144-43-1
N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-6,8-dimethylimidazo-[1,2-b]pyridazin-3-yl)ethanamide

Guidance literature:: N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

2-fluoroethyl tosylate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Product distribution / selectivity;

Reference yield: 47.0%

: 1163144-41-9
N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide

: 6315-52-2
1,2-bis-tosyloxyethane

: 1163144-42-0
2-(4-(3-(2-(diethylamino)-2-oxoethyl)-6,8-dimethylimidazo[1,2-b]pyridazin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: N,N-diethyl-2-(2-(4-hydroxyphenyl)-6,8-dimethylimidazo[1,2-b]pyridazin-3-yl)ethanamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

1,2-bis-tosyloxyethane; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Product distribution / selectivity;