Technology Process of C18H19NO5
There total 7 articles about C18H19NO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
15-crown-5; sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 17h;
stereoselective reaction;
DOI:10.1016/j.tetlet.2013.07.115
- Guidance literature:
-
Multi-step reaction with 5 steps
1: titanium(IV) isopropylate / toluene / 12 h / 100 °C
2: zinc(II) chloride / diethyl ether / -78 - 25 °C
3: potassium hydroxide; water / methanol / Reflux
4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
5: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C
With
titanium(IV) isopropylate; 15-crown-5; water; sodium hydride; potassium carbonate; potassium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2013.07.115
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 0 - 30 °C
2: titanium(IV) isopropylate / toluene / 12 h / 100 °C
3: zinc(II) chloride / diethyl ether / -78 - 25 °C
4: potassium hydroxide; water / methanol / Reflux
5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
6: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C
With
titanium(IV) isopropylate; aluminum (III) chloride; 15-crown-5; water; sodium hydride; potassium carbonate; potassium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
1: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2013.07.115
