(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

Base Information

Chemical Name:(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester
CAS No.:189280-04-4
Molecular Formula:C₂₆H₄₁N₃O₅
Molecular Weight:475.629
Hs Code.:

Synonyms:(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

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Chemical Property of (2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

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Technology Process of (2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

There total 7 articles about (2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 151-50-8
potassium cyanide

: 189279-99-0
(S)-6-[Benzyl-((S)-3-chloro-2-hydroxy-propyl)-amino]-2-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

: 189280-04-4
(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

Guidance literature:: With 18-crown-6 ether; In acetonitrile; at 45 ℃; for 120h;
DOI:10.1021/jo970119z

Reference yield: 70.0%

: 189280-04-4
(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

Guidance literature:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189280-04-4
(2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaHCO₃ / 1.) H₂O, CHCl₃, room temperature, 5 min, 2.) CHCl₃, reflux, 1.5 h.

2: 99 percent / H₂, 1N HCl / ethanol / 12 h

4: 77 percent / MgSO₄ / methanol / 72 h

5: 70 percent / 18-crown-6 / acetonitrile / 120 h / 45 °C

With hydrogenchloride; 18-crown-6 ether; hydrogen; sodium hydrogencarbonate; magnesium sulfate; In methanol; ethanol; acetonitrile;
DOI:10.1021/jo970119z