15-Oxa-2,7,13-triazaheptadecanoic acid, 12-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-16,16-dimethyl-14-oxo-7-[( phenylmethoxy)carbonyl]-, phenylmethyl ester, (5R,12S)-

Base Information

• Chemical Name: 15-Oxa-2,7,13-triazaheptadecanoic acid, 12-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-16,16-dimethyl-14-oxo-7-[( phenylmethoxy)carbonyl]-, phenylmethyl ester, (5R,12S)-
• CAS No.: 189280-15-7
• Molecular Formula: C35H51N3O9
• Molecular Weight: 657.805

Synonyms:

Chemical Property of 15-Oxa-2,7,13-triazaheptadecanoic acid, 12-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-16,16-dimethyl-14-oxo-7-[( phenylmethoxy)carbonyl]-, phenylmethyl ester, (5R,12S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 15-Oxa-2,7,13-triazaheptadecanoic acid, 12-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-16,16-dimethyl-14-oxo-7-[( phenylmethoxy)carbonyl]-, phenylmethyl ester, (5R,12S)-

There total 15 articles about 15-Oxa-2,7,13-triazaheptadecanoic acid, 12-[(1,1-dimethylethoxy)carbonyl]-5-hydroxy-16,16-dimethyl-14-oxo-7-[( phenylmethoxy)carbonyl]-, phenylmethyl ester, (5R,12S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzyl chloroformate (501-53-1,94274-21-2) + tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-azaundecanoate (260783-38-8) → tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(benzyloxycarbonyl)-7-azaundecanoate (189280-15-7)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 1.5h;

DOI:10.1016/S0957-4166(99)00474-7

Reference yield: 55.0%

benzyl chloroformate (501-53-1,94274-21-2) + (2S,9R)-2-[(tert-Butoxycarbonyl)amino]-11-amino-9-hydroxy-7-azaundecanoic Acid tert-Butyl Ester, Diacetate Salt → tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(benzyloxycarbonyl)-7-azaundecanoate (189280-15-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;

Reference yield: 50.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + (2S,9R)-2-[(tert-Butoxycarbonyl)amino]-11-amino-9-hydroxy-7-azaundecanoic Acid tert-Butyl Ester, Diacetate Salt → tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(benzyloxycarbonyl)-7-azaundecanoate (189280-15-7)

Guidance literature:

With potassium hydrogencarbonate; In diethyl ether; for 4h; Ambient temperature;

DOI:10.1021/jm980389p

upstream raw materials:

benzyl chloroformate

N-(Benzyloxycarbonyloxy)succinimide

tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-azaundecanoate

(R)-4-(benzyloxycarbonyl)amino-1,2-butanediol

Downstream raw materials:

2(S)-Amino-11-[(benzyloxycarbonyl)amino]7-(carbobenzyloxy)-7-azaundecanoic Acid

deoxyhypusine

(2S,9R)-2-Amino-11-[(Benzyloxycarbonyl)amino]-7-(carbobenzyloxy)-9-(tetrahydropyran-2-yloxy)-7-azaundecanoic Acid

11-[(Benzyloxycarbonyl)amino]-7-(carbobenzyloxy)-2(S)-[(9-fluorenylmethoxycarbonyl)amino]-7-azaundecanoic Acid

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