(3R)-(-)-3-Phenylheptanal

Base Information

• Chemical Name: (3R)-(-)-3-Phenylheptanal
• CAS No.: 75991-48-9
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 190.285
• Mol file: 75991-48-9.mol

Synonyms:(3R)-(-)-3-Phenylheptanal

Chemical Property of (3R)-(-)-3-Phenylheptanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-(-)-3-Phenylheptanal

There total 9 articles about (3R)-(-)-3-Phenylheptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-Heptenal (18829-55-5) + phenylboronic acid (98-80-6) → (3S)-3-phenylheptanal (72656-59-8) + (3R)-(-)-3-Phenylheptanal (75991-48-9)

Guidance literature:

With potassium hydroxide; bis(ethylene)rhodium(I) chloride dimer; (1R,4R)-2,5-dibenzylbicyclo[2.2.1]hepta-2,5-diene; In tetrahydrofuran; methanol; water; at 10 ℃; for 6h; Title compound not separated from byproducts;

DOI:10.1246/cl.2005.1480

Reference yield:

(R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether (84999-94-0) → (3R)-(-)-3-Phenylheptanal (75991-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / t-BuOK/diisopropylamine/butyllithium / diethyl ether / -100 °C

2: aq. 40percent HClO₄ / diethyl ether

With n-butyllithium; perchloric acid; potassium tert-butylate; diisopropylamine; In diethyl ether;

DOI:10.1246/cl.1982.1637

Reference yield:

C23H30O2 (84999-97-3) → (3S)-3-phenylheptanal (72656-59-8) + (3R)-(-)-3-Phenylheptanal (75991-48-9)

Guidance literature:

With perchloric acid; In diethyl ether; Yield given. Yields of byproduct given;

DOI:10.1246/cl.1982.1637

upstream raw materials:

1-bromo-butane

(S)-(-)-1-Cinnamyl-(2-methoxymethyl)pyrrolidin

(S)-4-tert-Butyl-2-((R)-2-phenyl-hexyl)-4,5-dihydro-oxazole

C₂₃H₃₀O₂

Downstream raw materials:

(3R)-3-phenylheptan-1-ol

(3S)-3-phenylheptan-1-ol

Acetic acid (R)-3-phenyl-heptyl ester

Acetic acid (S)-3-phenyl-heptyl ester