[3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl](2,4-dichlorophenyl)methanone

Base Information

• Chemical Name: [3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl](2,4-dichlorophenyl)methanone
• CAS No.: 361185-80-0
• Molecular Formula: C₁₇H₁₄Cl₂N₂O₂S
• Molecular Weight: 381.282
• Mol file: 361185-80-0.mol

Synonyms:(3-amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone

Chemical Property of [3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl](2,4-dichlorophenyl)methanone

Chemical Property:

Purity/Quality:

[3-AMINO-4-(METHOXYMETHYL)-6-METHYLTHIENO[2,3-B]PYRIDIN-2-YL]-(2,4-DICHLOROPHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl](2,4-dichlorophenyl)methanone

There total 1 articles about [3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl](2,4-dichlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(methoxymethyl)-6-methyl-3-cyanopyridine-2(1H)-thione (31681-83-1) → (3-amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone (361185-80-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1023/B:COHC.0000028636.31350.c0

Reference yield: 83.0%

(3-amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone (361185-80-0) → (3-azido-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone (496931-63-6)

Guidance literature:

(3-amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone; With sulfuric acid; acetic acid; sodium nitrite; at 5 - 7 ℃;

With sodium azide;

DOI:10.1023/B:COHC.0000028636.31350.c0

Reference yield: 26.0%

(3-amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone (361185-80-0) → 2-(2,4-dichlorophenyl)-4,9-di(methoxymethyl)-6,11-dimethyldipyrido[3',2':4,5]thieno[3,2-b:3,2-d]pyridine (1002788-87-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 3h; Heating;

DOI:10.1007/s10593-006-0251-7

upstream raw materials:

4-(methoxymethyl)-6-methyl-3-cyanopyridine-2(1H)-thione

Downstream raw materials:

(3-azido-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-2-yl)-(2,4-dichloro-phenyl)-methanone

2-(2,4-dichlorophenyl)-4,9-di(methoxymethyl)-6,11-dimethyldipyrido[3',2':4,5]thieno[3,2-b:3,2-d]pyridine