N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

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Chemical Name:N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide
CAS No.:910234-64-9
Molecular Formula:C₃₅H₄₁N₇O₃
Molecular Weight:607.756
Hs Code.:

Synonyms:N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

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Chemical Property of N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

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Technology Process of N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

There total 7 articles about N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₉N₇O₅

: 910234-64-9
N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

: C₁₈H₂₀BrN₅O₄

: 910234-64-9
N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

: 1710-98-1
p-tert-butyl benzoyl chloride

: 910234-64-9
N-(3-{6-[3-amino-4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl}-2-methyl-phenyl)-4-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 - 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.001