ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate

Base Information

• Chemical Name: ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate
• CAS No.: 1168134-65-3
• Molecular Formula: C₁₆H₁₇BrClF₃O₃
• Molecular Weight: 429.661
• Mol file: 1168134-65-3.mol

Synonyms:ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate

Chemical Property of ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate

There total 5 articles about ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)acetate (1168134-12-0) + cyclopropylcarbinyl bromide (7051-34-5) → ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate (1168134-65-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

Reference yield:

(4-hydroxy-phenyl)-acetic acid ethyl ester (17138-28-2) → ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate (1168134-65-3)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine / chloroform / 1 h / 0 °C

2: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 °C / Inert atmosphere

With sulfuryl dichloride; bromine; sodium hydride; potassium carbonate; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; paraffin oil;

Reference yield:

3-chloro-4-hydroxyphenylacetic acid ethyl ester (193357-36-7) → ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)-3-cyclopropylpropanoate (1168134-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform / 1 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 °C / Inert atmosphere

With bromine; sodium hydride; potassium carbonate; In chloroform; N,N-dimethyl-formamide; paraffin oil;

upstream raw materials:

ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)acetate

cyclopropylcarbinyl bromide

3-chloro-4-hydroxyphenylacetic acid ethyl ester

(4-hydroxy-phenyl)-acetic acid ethyl ester