tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
CAS No.:1581303-55-0
Molecular Formula:C₂₇H₂₉N₃O₄S
Molecular Weight:491.611
Hs Code.:

Synonyms:tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 103-82-2
phenylacetic acid

: 1581303-59-4
(Z)-tert-butyl 4-((2-(N'-hydroxycarbamimidoyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

: 1581303-55-0
tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: (Z)-tert-butyl 4-((2-(N'-hydroxycarbamimidoyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

phenylacetic acid; In N,N-dimethyl-formamide; at 140 ℃; for 3h;
DOI:10.1021/jm500066b

Reference yield:

: 1581303-58-3
tert-butyl 4-((2-cyanobenzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

: 1581303-55-0
tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine / ethanol; water / 4 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 3 h / 140 °C

With hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500066b

Reference yield:

: 57477-69-7
3-hydroxy[1]benzothiophene-2-carbonitrile

: 1581303-55-0
tert-butyl 4-((2-(5-benzyl-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 4 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 3 h / 140 °C

With di-isopropyl azodicarboxylate; hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500066b