57477-69-7Relevant articles and documents
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)
Rackham, Mark D.,Brannigan, James A.,Rangachari, Kaveri,Meister, Stephan,Wilkinson, Anthony J.,Holder, Anthony A.,Leatherbarrow, Robin J.,Tate, Edward W.
supporting information, p. 2773 - 2788 (2014/04/17)
N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme and an attractive drug target in parasitic infections such as malaria. We have previously reported that 2-(3-(piperidin-4-yloxy)benzo[b]thiophen-2-yl)-5-((1,3, 5-trimethyl-1H-pyrazol-4-yl)meth
Polycyclic N-heterocyclic compounds. 57 Syntheses of fused furo(or thieno)[2,3-b]pyridine derivatives via smiles rearrangement and cyclization
Hirota, Takashi,Tomita, Kei-Ichiroh,Sasaki, Kenji,Okuda, Kensuke,Yoshida, Masahiko,Kashino, Setsuo
, p. 741 - 752 (2007/10/03)
An efficient methodology for the synthesis of thieno[2,3-c][2,7]-naphthyridine (6), thieno[2,3-c]isoquinoline (11), furo[2,3-c]isoquinoline (14), [1]benzothieno[3,2-d]thieno[2,3-b]pyridine (21), and [1]benzothieno[3,2-d]furo-[2,3-b]pyridine (26) skeletons from 4-[o-cyanoarylthio(or oxy)]butyronitriles with base via Smiles type rearrangement reaction followed by the cyclization is described.
Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives
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, (2008/06/13)
Herein is disclosed 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for