Technology Process of 6-β-phenylacetamido-2-oxo-penam
There total 6 articles about 6-β-phenylacetamido-2-oxo-penam which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) NaIO4 / 1) H2O; 2) NEt3, DMF, 20 deg C
2: 65 percent Chromat. / MgSO4, (CH3O)3P / benzene / 40 h / Heating
3: 74 percent / KMnO4, MgSO4 / H2O; ethanol / 15 - 20 °C
4: 1) Triton B / 1) DMF, CH3OH, -30 deg C, 15 min; 0 deg C, 15 min; 2) DMF, 15 min, -30 deg C; 1 h, 0 deg C; 2 h, r. t.
5: 79 percent / HCl / methanol; H2O / 0.5 h / Ambient temperature
6: 81 percent / N,N-diisopropylcarbodiimide / CH2Cl2 / 0.5 h / -25 -> 20 deg C, 4 h
With
hydrogenchloride; potassium permanganate; sodium periodate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; diisopropyl-carbodiimide; phosphorous acid trimethyl ester;
In
methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1016/S0040-4020(01)92143-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 65 percent Chromat. / MgSO4, (CH3O)3P / benzene / 40 h / Heating
2: 74 percent / KMnO4, MgSO4 / H2O; ethanol / 15 - 20 °C
3: 1) Triton B / 1) DMF, CH3OH, -30 deg C, 15 min; 0 deg C, 15 min; 2) DMF, 15 min, -30 deg C; 1 h, 0 deg C; 2 h, r. t.
4: 79 percent / HCl / methanol; H2O / 0.5 h / Ambient temperature
5: 81 percent / N,N-diisopropylcarbodiimide / CH2Cl2 / 0.5 h / -25 -> 20 deg C, 4 h
With
hydrogenchloride; potassium permanganate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; diisopropyl-carbodiimide; phosphorous acid trimethyl ester;
In
methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1016/S0040-4020(01)92143-X
