54275-92-2

Upstream product

• 69-57-8 Penicillin G sodium 
• 100-39-0 benzyl bromide 

Downstream Products

• 78037-14-6 (R)-2-((1S,5R)-3-Benzyl-7-oxo-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid benzyl ester 
• 76757-87-4 6-Deuteriobenzylpenicillin (S)-S-Oxide Benzyl Ester 
• 76757-88-5 C₂₃H₂₃⁽²⁾HN₂O₅S 
• 87996-76-7 2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-2-enoic acid benzyl ester 
• 76757-89-6 6α-Deuteriobenzylpenicillin Benzyl Ester 
• 731751-10-3 6α-Deuteriobenzylpenicillin 
• 34103-69-0 (1E,5R)-3-Phenylmethyl-4-thia-2,6-diazabicyclo[3.2.0]hept-2-en-7-one 
• 87996-92-7 (6R)-phenylacetamido-2-benzoyloxy-(5R)-penem-3-p-nitrobenzyl-carboxylate 
• 78815-25-5 (6R)-phenylacetamido-2-methoxy-(5R)-penem-3-p-nitrobenzyl-carboxylate 
• 78815-06-2 2-((2R,3R)-2-Mercapto-4-oxo-3-phenylacetylamino-azetidin-1-yl)-malonic acid mono-(4-nitro-benzyl) ester 
• 78815-20-0 2-((2R,3R)-2-Mercapto-4-oxo-3-phenylacetylamino-azetidin-1-yl)-malonic acid monobenzhydryl ester 
• 78815-29-9 (6R)-phenylacetamido-2-benzoyloxy-(5R)-penem-3-t-butyl-carboxylate 
• 78815-23-3 2-oxo-bisnorpenicillin G-3-p-nitrobenzyl carboxylate 
• 78815-03-9 2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-mono-p-nitrobenzyl malonate 

Relevant academic research and scientific papers

Synthesis of 2-oxo-penams and penems from penicillin G

Using Penicillin G as starting material, general methods of synthesis for the 2-oxo-penam skeleton have been established. Compounds 7 represent a new group of strained penicillin derivatives. They can be readily transformed into 2-alkoxy 17 or benzoyloxypenems 18.