(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

Base Information

Chemical Name:(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide
CAS No.:730958-87-9
Molecular Formula:C₂₄H₃₂N₂O
Molecular Weight:364.531
Hs Code.:

Synonyms:(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

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Chemical Property of (R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

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Technology Process of (R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

There total 4 articles about (R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 730958-86-8
(R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-1-en-1-yl trifluoromethanesulfonate

: 730958-83-5
3-(diethylcarbamoyl)-1-methyl-1H-indol-2-ylboronic acid

: 730958-87-9
(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 12h;
DOI:10.1021/ol049780x

Reference yield:

: 120-72-9
indole

: 730958-87-9
(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / AlCl₃ / CH₂Cl₂ / 5 h / Heating

2.1: 98 percent / NaH / tetrahydrofuran / 12 h / 20 °C

3.1: s-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: B(OMe)3 / hexane; tetrahydrofuran / -78 - 20 °C

3.3: NH₄Cl / hexane; tetrahydrofuran; H₂O

4.1: 91 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 12 h / 100 °C

With potassium phosphate; aluminium trichloride; sec.-butyllithium; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ol049780x

Reference yield:

: 61788-23-6
N,N-diethyl-1H-indole-3-carboxamide

: 730958-87-9
(R)-N,N-diethyl-1-methyl-2-(2-methyl-5-(prop-1-en-2-yl)cyclohex-1-enyl)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / NaH / tetrahydrofuran / 12 h / 20 °C

2.1: s-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: B(OMe)3 / hexane; tetrahydrofuran / -78 - 20 °C

2.3: NH₄Cl / hexane; tetrahydrofuran; H₂O

3.1: 91 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 12 h / 100 °C

With potassium phosphate; sec.-butyllithium; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 3.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ol049780x