7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

Base Information

Chemical Name:7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III
CAS No.:259522-68-4
Molecular Formula:C₄₇H₇₇N₃O₁₀Si₃
Molecular Weight:928.399
Hs Code.:

Synonyms:7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

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Chemical Property of 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

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Technology Process of 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

There total 5 articles about 7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1843-35-2
3-azidobenzoic acid

: 204580-30-3
10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III

: 259522-68-4
7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 40 ℃; for 40h;
DOI:10.1021/jm800086e

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 259522-68-4
7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / imidazole / dimethylformamide / 40 h / 20 °C

2: 97 percent / Red-Al / tetrahydrofuran / -10 °C

3: DIC; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; dacarbazine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: silylation / 2: debenzoylation / 3: Esterification;
DOI:10.1016/S0960-894X(99)00629-0

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 259522-68-4
7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-azidobenzoyl)-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Red-Al / tetrahydrofuran / -10 °C

2: DIC; DMAP / CH₂Cl₂

With dmap; dacarbazine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; 1: debenzoylation / 2: Esterification;
DOI:10.1016/S0960-894X(99)00629-0