(S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide

Base Information

• Chemical Name: (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide
• CAS No.: 125198-28-9
• Molecular Formula: C₁₅H₂₂N₂O₄
• Molecular Weight: 294.351
• Mol file: 125198-28-9.mol

Synonyms:(S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide

Chemical Property of (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide

There total 7 articles about (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide (101460-68-8) → (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide (125198-28-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h; under 760 Torr;

DOI:10.1021/jm00166a012

Reference yield:

3,6-Bis-benzyloxy-2-methoxy-benzoyl chloride → (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide (125198-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 760 Torr

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jo00065a015

Reference yield:

3,6-bis(benzyloxy)-2-methoxybenzoic acid (101460-69-9) → (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide (125198-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂, DMF / toluene / 1.5 h / 60 °C

2: CH₂Cl₂

3: 92 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 760 Torr

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; dichloromethane; toluene;

DOI:10.1021/jo00065a015

upstream raw materials:

(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

methoxyhydroquinone

3,6-bis(benzyloxy)-2-methoxybenzoic acid

3,6-Dihydroxy-2-methoxybenzoic acid

Downstream raw materials:

NCQ 344