(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

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Chemical Name:(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile
CAS No.:1425042-18-7
Molecular Formula:C₂₈H₂₃N₇O₂
Molecular Weight:489.536
Hs Code.:

Synonyms:(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

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Chemical Property of (S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

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Technology Process of (S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

There total 4 articles about (S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 762262-09-9
(2-methoxypyridin-4-yl)boronic acid

: 1425042-18-7
(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate monohydrate / butan-1-ol; water / 0.5 h / 25 °C / Inert atmosphere; Large scale

1.2: 4.17 h / 80 °C / Inert atmosphere; Large scale

2.1: butan-1-ol; water / 20 °C / Inert atmosphere; Large scale

2.2: 90 °C / Inert atmosphere; Large scale

With potassium phosphate monohydrate; In water; butan-1-ol;

Reference yield:

: 1393179-35-5
2-amino-4-chloropyrimidine-5-carbonitrile

: 1425045-77-7
C₂₃H₂₁N₃O₂

: 1425042-18-7
(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

Guidance literature:: 2-amino-4-chloropyrimidine-5-carbonitrile; C₂₃H₂₁N₃O₂; In water; butan-1-ol; at 20 ℃; Inert atmosphere; Large scale;

With N-ethyl-N,N-diisopropylamine; In water; butan-1-ol; at 90 ℃; Inert atmosphere; Large scale;

Reference yield:

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

: 1425042-18-7
(S)-2-amino-4-((1-(8-(2-methoxypyridin-4-yl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate monohydrate / butan-1-ol; water / 0.5 h / 25 °C / Inert atmosphere; Large scale

1.2: 4.17 h / 80 °C / Inert atmosphere; Large scale

2.1: butan-1-ol; water / 20 °C / Inert atmosphere; Large scale

2.2: 90 °C / Inert atmosphere; Large scale

With potassium phosphate monohydrate; In water; butan-1-ol;