5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Base Information

• Chemical Name: 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine
• CAS No.: 1607820-53-0
• Molecular Formula: C₁₈H₂₂N₆O₃S
• Molecular Weight: 402.477

Synonyms:5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Chemical Property of 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

There total 10 articles about 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyrrolidine (123-75-1) + 4-ethoxy-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazin-5-yl)benzene-1-sulfonyl chloride (1607820-48-3) → 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-53-0)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2014.10.009

Reference yield:

(2-ethoxyphenyl)boronic acid (213211-69-9) → 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2014.03.029

Reference yield:

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine (682319-80-8) → 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2014.03.029

upstream raw materials:

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine

(2-ethoxyphenyl)boronic acid

3-(2-ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazine

pyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1607820-53-0 5-[2-ethoxy-5-(pyrrolidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send