methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 1315321-14-2
• Molecular Formula: C₂₃H₂₈N₂O₄
• Molecular Weight: 396.486

Synonyms:methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 2 articles about methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-octyn-1-ol (20739-58-6) + methyl 3-acetyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (330567-73-2) → methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1315321-14-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol2015658

Reference yield:

5-methoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (188780-24-7) → methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1315321-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1021/ol2015658

Reference yield: 89.0%

methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1315321-14-2) → methyl 6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1315320-83-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol2015658

upstream raw materials:

2-octyn-1-ol

methyl 3-acetyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

5-methoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Downstream raw materials:

methyl 6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

methyl 1-oxo-6-pentyl-3-phenyl-2,3,7,8-tetrahydro-1H-pyrido[1,2-c]pyrimidine-4-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1315321-14-2 methyl 3-acetyl-6-methyl-1-(oct-2-yn-1-yl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send