188780-24-7

Upstream product

• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 57-13-6 urea 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 624-45-3 levulinic acid methyl ester 
• 497-19-8 sodium carbonate 
• 674-82-8 4-methyleneoxetan-2-one 
• 67-56-1 methanol 
• 555-16-8 4-nitrobenzaldehdye 
• 100-51-6 benzyl alcohol 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 75-07-0 acetaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 1061863-12-4 C₁₇H₂₂N₂O₃ 
• 1254120-75-6 C₂₀H₁₈N₂O₄ 
• 1393740-82-3 5-methoxycarbonyl-6-methyl-3-(diaminophosphinyl)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1393740-75-4 C₁₃H₁₃Cl₂N₂O₄P 
• 1315321-08-4 C₁₇H₁₇⁽²⁾HN₂O₃ 
• 1315321-07-3 C₁₇H₁₇⁽²⁾HN₂O₃ 
• 1315321-06-2 C₁₇H₁₅⁽²⁾H₃N₂O₃ 
• 1315321-05-1 C₁₇H₁₂⁽²⁾H₆N₂O₃ 
• 1315321-04-0 C₁₈H₁₄⁽²⁾H₆N₂O₃ 

Relevant academic research and scientific papers

An efficient protocol for the liquid-phase synthesis of methyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylate derivatives

Methyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylate derivatives 7 were effectively synthesized on the soluble polymer of polyethylene glycol (PEG) 4000 by heating or solvent-free microwave irradiation through the Biginelli three-component cyclocondensation. Compared with the classical solution-phase Biginelli reactions, the yields could be considerably improved and the reaction time could be shortened dramatically under microwave promotion in a liquid-phase protocol. Moreover, the polymer-supported synthesis provided the target compounds in high purity.

Tetrabutylammonium hydrogen sulfate: An efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

Tetrabutylammonium hydrogen sulfate (TBAHS) as a solid protic acid and phase-transfer reagent catalyzed the three-component condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1H)-ones in high yields at 80 C.

Perlite: A cheap natural support for immobilization of sulfonic acid as a heterogeneous solid acid catalyst for the heterocyclic multicomponent reaction

Perlite sulfonic acid (Perlite-SO3H (PeSA)) has been synthesized by grafting the sulfonic groups on the perlite surface as naturally and cheap support to produce novel heterogeneous reusable solid acid catalysts. FT-IR, XRD, SEM, TGA, pH analysis and Hammett acidity function were employed to characterize the properties of the synthesized PeSA. Significantly, the as-prepared PeSA exhibits a high catalytic activity in multicomponent reaction for the one-pot synthesis of heterocyclic compound such as 3,4-dihydropyrimidin-2(1H)-ones, 2,4,5-trisubstituted imidazoles, coumarins and bis(indolyl)methanes. Additionally, the newly synthesized heterogeneous solid acid catalyst can be reused for several times without apparent loss of its catalytic activity, confirming the stability of the covalent bonding of acidic centers. PeSA has advantages such as low cost, ease of preparation, more stability and reusability, low toxicity and ease of handling.

Soluble polymer-supported synthesis of Biginelli compounds

An efficient and general liquid-phase synthesis of Biginelli compounds has been developed. Polyethylene glycol (PEG) bound acetoacetate reacted with urea and aldehydes under reflux or solvent-free microwave irradiation conditions to afford PEG-supported 3

Eosin Y photocatalyzed access to Biginelli reaction using primary alcohols via domino multicomponent cascade: an approach towards sustainable synthesis of 3,4-dihydropyrimidin-2(1H)-ones

The Eosin Y photocatalyzed Biginelli protocol has been established by a cascade one-pot three-component reaction of primary alcohols, α-ketoester, and urea to provide pharmacologically promising 3,4-dihydropyrimidin-2(1H)-ones in high yields. The key benefits of the present scheme are the capability to allow operational simplicity, readily available substrates, straightforward workup and high yields. This Eosin Y based photocatalytic approach can permit conquering traditional metal-catalyzed reactions in a sustainable manner, thus delivering economic and environmental rewards. Graphical abstract: An environmentally benign protocol for the synthesis of 3,4-DHPMs has been developed using inexpensive molecular oxygen, visible light as green energy source and eosin Y as photoreceptor-cum-sensitizer. The utilized photoreceptor revealed its unique properties in rapid intersystem crossing, high photo and chemical stability, ease of separation and high catalytic efficiency.[Figure not available: see fulltext.].

The new life of traditional water treatment flocculant polyaluminum chloride (PAC): A green and efficient micro-nano reactor catalyst in alcohol solvents

Polyaluminum chloride (PAC) is an inorganic polymer material that has the advantages of a simple preparation process and special electronic structure. It is considered to be the most efficient and widely used flocculation material for water treatment. In

Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction

A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B

Chitosan-silica sulfate nano hybrid: An efficient biopolymer based-heterogeneous nano catalyst for solvent-free synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones

A green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free c

Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst

Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C

Synthesis and characterization of the immobilized polythiophene on magnetic carbon nanotube as a prominent catalyst for the synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives

Abstract: In this work, the immobilized polythiophene on magnetic carbon nanotube (CNT–Fe3O4–PTh) was synthesized and introduced as a novel and recoverable catalytic system. The prepared magnetic heterogeneous nanocatalyst was characterized by FT-IR, TGA, EDX, VSM, XRD, TEM, and FE-SEM. Next, the catalytic efficiency of CNT–Fe3O4–PTh was evaluated through the green synthesis of a variety of dihydropyrimidinone and octahydroquinazolinone through Biginelli reaction between aromatic aldehydes, urea/thiourea, and β-dicarbonyl compounds under solvent-free conditions. The catalyst was magnetically recovered and recycled for five cycles without a discernible loss in its catalytic activity. Simple workup, affordability, short reaction times, mild reaction conditions, and the high yield of products are the interesting features of this project. Graphic abstract: An environmentally benign nanocomposite was prepared using carbon nanotube as an inexpensive, nontoxic, and stable support in the preparation of CNT–Fe3O4–PTh, which was efficiently used as catalyst for the green synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives through Biginelli reaction under solvent-free conditions.[Figure not available: see fulltext.].