6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

Base Information

Chemical Name:6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.
CAS No.:1380089-91-7
Molecular Formula:C₁₈H₁₄ClN₃O
Molecular Weight:323.782
Hs Code.:

Synonyms:6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

Chemical Property:

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Technology Process of 6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

There total 10 articles about 6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380089-92-8
4-azido-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepine

: 1380089-91-7
6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

Guidance literature:: With water; trimethylphosphane; In tetrahydrofuran; toluene; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1380089-91-7
6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3.1: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: trimethylphosphane / toluene / 2 h / 20 °C / Resealable vial; Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C

8.2: 1 h / 0 °C

9.1: water / trimethylphosphane / toluene; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sodium azide; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; triethylamine; trimethylphosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethyl sulfoxide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1380089-91-7
6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine.

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3.1: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: trimethylphosphane / toluene / 2 h / 20 °C / Resealable vial; Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C

8.2: 1 h / 0 °C

9.1: water / trimethylphosphane / toluene; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sodium azide; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; triethylamine; trimethylphosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethyl sulfoxide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;