2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide
CAS No.:1146361-91-2
Molecular Formula:C₁₂H₁₃F₄NO₂
Molecular Weight:279.234
Hs Code.:

Synonyms:2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

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Chemical Property of 2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

There total 3 articles about 2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917-64-6
methyl magnesium iodide

: 1146361-89-8
methyl (R)-(4-fluorophenyl)-(2,2,2-trifluoracetylamino)-acetate

: 1146361-91-2
2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

Guidance literature:: methyl magnesium iodide; methyl (R)-(4-fluorophenyl)-(2,2,2-trifluoracetylamino)-acetate; In tetrahydrofuran; at 3 - 20 ℃; for 12h;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 93939-74-3
(R)-2-(4-fluorophenyl)glycine

: 1146361-91-2
2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 12 h / 20 °C / Cooling with ice

2: triethylamine / tetrahydrofuran / 12 h / -70 - 20 °C

3: tetrahydrofuran / 12 h / 3 - 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 170902-76-8
methyl (R)-amino-(4-fluorophenyl)-acetate

: 1146361-91-2
2,2,2-trifluoro-N-[(R)-1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 12 h / -70 - 20 °C

2: tetrahydrofuran / 12 h / 3 - 20 °C

With triethylamine; In tetrahydrofuran;