methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Base Information

Chemical Name:methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate
CAS No.:1436855-82-1
Molecular Formula:C₃₀H₃₄ClN₃O₃
Molecular Weight:520.071
Hs Code.:

Synonyms:methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Chemical Property of methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Technology Process of methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

There total 14 articles about methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 68470-59-7
2-(bromomethyl)-6-methylpyridine

: 1436855-56-9
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

: 1436855-82-1
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 100.0%

: 1436855-82-1
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1436855-51-4
(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-82-1
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-((6-methylpyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 3 h / 10 - 25 °C

2: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3: water; hydrogenchloride / 18 h / 100 °C

4: sulfuric acid / water / 18 h / Reflux

5: perchloric acid / dichloromethane / 4 h / 0 - 20 °C

6: potassium hydroxide; tetrabutylammomium bromide / dichloromethane / 4 h / 20 °C

With hydrogenchloride; perchloric acid; sulfuric acid; tetrabutylammomium bromide; water; sulfur trioxide pyridine complex; triethylamine; potassium hydroxide; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide;