methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Base Information

Chemical Name:methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate
CAS No.:1436855-56-9
Molecular Formula:C₂₃H₂₇ClN₂O₃
Molecular Weight:414.932
Hs Code.:

Synonyms:methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Chemical Property of methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Technology Process of methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

There total 13 articles about methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 540-88-5
acetic acid tert-butyl ester

: 1436855-55-8
methyl 2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

: 1436855-56-9
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: With perchloric acid; In dichloromethane; ethyl acetate; at 0 - 20 ℃; for 4h;

Reference yield:

: 1436855-50-3
(4-chloro-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-56-9
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

3: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

4: hydrogenchloride / water / 18 h / 100 °C

5: sulfuric acid / 18 h / Reflux

6: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; sulfuric acid; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; zinc(II) iodide; In dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 1436855-52-5
4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridine-5-carboaldehyde

: 1436855-56-9
methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

2: hydrogenchloride / water / 18 h / 100 °C

3: sulfuric acid / 18 h / Reflux

4: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C

With hydrogenchloride; perchloric acid; sulfuric acid; zinc(II) iodide; In dichloromethane; water; ethyl acetate;