8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde
• CAS No.: 175878-16-7
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID901243593
• Nikkaji Number: J2.961.691D
• Mol file: 175878-16-7.mol

Synonyms:175878-16-7;8-methylimidazo[1,2-a]pyridine-3-carbaldehyde;8-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carboxaldehyde, 8-methyl- (9CI);8-methylimidazo[1,2-a]pyridine-3-carboxaldehyde;IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE,8-METHYL-;8-Methyl-imidazo[1,2-a]pyridine-3-carbaldehyde;SCHEMBL5632902;DTXSID901243593;MFCD09994355;AKOS006310732;AM806336;AS-39591;CS-0036361;EN300-84820;imidazo[1,2-a]pyridine-3-carbaldehyde,8-methyl-;Z1198268070

Chemical Property of 8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property:

• PKA: 4.68±0.50(Predicted)
• PSA: 34.37000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.45520
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 183

Purity/Quality:

97% ^*data from raw suppliers

8-Methyl-imidazo[1,2-A]pyridine-3-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CN2C1=NC=C2C=O

Technology Process of 8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

There total 1 articles about 8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-methyl-N-(prop-2-yn-1-yl)pyridin-2-amine (1250146-65-6) → 3,8-dimethylimidazo[1,2-a]pyridine (1284210-50-9) + 8-methylimidazo<1,2-a>pyridine-3-carboxaldehyde (175878-16-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; oxygen; silver nitrate; In acetonitrile; at 60 ℃; for 2h;

DOI:10.1021/jo3025303

Reference yield: 98.0%

8-methylimidazo<1,2-a>pyridine-3-carboxaldehyde (175878-16-7) → (8-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol (178488-40-9)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1021/jm9507901

Reference yield:

8-methylimidazo<1,2-a>pyridine-3-carboxaldehyde (175878-16-7) → 3-Benzylsulfanylmethyl-8-methyl-imidazo[1,2-a]pyridine

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / NaBH₄ / methanol

2: SOCl₂ / Heating

3: pyridine / acetonitrile / Heating

With pyridine; sodium tetrahydroborate; thionyl chloride; In methanol; acetonitrile;

DOI:10.1021/jm9507901

upstream raw materials:

3-methyl-N-(prop-2-yn-1-yl)pyridin-2-amine

Downstream raw materials:

(8-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol

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