tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate
CAS No.:1433404-96-6
Molecular Formula:C₂₉H₃₉ClFNO₄Si
Molecular Weight:548.17
Hs Code.:

Synonyms:tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

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Chemical Property of tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

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Technology Process of tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

There total 7 articles about tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433402-10-8
[(R)-(4-chloro-2-fluoro-phenyl)-cyclopropyl-methyl]-carbamic acid tert-butyl ester

: 139706-48-2
4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester

: 1433404-96-6
tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

Guidance literature:: [(R)-(4-chloro-2-fluoro-phenyl)-cyclopropyl-methyl]-carbamic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; for 1h; Inert atmosphere; Cooling with acetone-dry ice;

4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester; In tetrahydrofuran; hexane; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1433404-96-6
tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1 h

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane;

Reference yield:

: 856562-58-8
(S)-(-)-2-methylpropane-2-sulfinic acid 1-(4-chloro-2-fluorophenyl)(E)methylideneamide

: 1433404-96-6
tert-butyl N-[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 6.5 h / -75 - 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Inert atmosphere; Cooling with acetone-dry ice

4.2: 1 h

With hydrogenchloride; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; ethyl acetate;