N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide

Base Information

Chemical Name:N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide
CAS No.:1372629-25-8
Molecular Formula:C₁₁H₁₄F₃NO₂S
Molecular Weight:281.299
Hs Code.:
DSSTox Substance ID:DTXSID001190412

Synonyms:N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide;SCHEMBL15946356;ZXBYMRXBWVSVOH-UHFFFAOYSA-N;DTXSID001190412;AKOS008940075;N-(1,1-Dimethylethyl)-4-(trifluoromethyl)benzenesulfonamide;1372629-25-8

Suppliers and Price of N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:281.06973435
Heavy Atom Count:18
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)NS(=O)(=O)C1=CC=C(C=C1)C(F)(F)F

Technology Process of N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide

There total 2 articles about N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 830-43-3
4-(trifluoromethyl)benzenesulfonamide

: 84379-72-6
1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate

: 1372629-25-8
N-(tert-butyl)-p-(trifluoromethyl)benzenesulfonamide

Guidance literature:: With lithium tetrafluoroborate; 12-phenyl-12H-benzo[b]phenothiazine; In dichloromethane; at 20 ℃; for 24h; Irradiation;
DOI:10.1002/cctc.202100803

Reference yield: 69.0%

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 75-64-9
tert-butylamine

: 1372629-25-8
N-(tert-butyl)-p-(trifluoromethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/ejoc.201101298

Reference yield: 48.0%

: 1372629-25-8
N-(tert-butyl)-p-(trifluoromethyl)benzenesulfonamide

: N-(tert-butyl)-N-fluoro-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: N-(tert-butyl)-p-(trifluoromethyl)benzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; hexane; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.202110233