2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:631919-31-8
Molecular Formula:C₂₃H₃₄O₄Si
Molecular Weight:402.606
Hs Code.:

Synonyms:2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

There total 5 articles about 2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 556-56-9
allyl iodid

: 3-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

: 631919-31-8
2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: 3-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

allyl iodid; In tetrahydrofuran; toluene; at -78 ℃; for 3h;
DOI:10.1021/ja030139k

Reference yield:

: 145958-02-7
(2S,4S)-2-phenyl-1,3-dioxane-4-carboxaldehyde

: 631919-31-8
2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / CH₂Cl₂ / 12 h / Heating

2.1: CuI; TMSCl / tetrahydrofuran / 2 h / -78 °C

3.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

3.2: 72 percent / tetrahydrofuran; toluene / 3 h / -78 °C

With copper(l) iodide; chloro-trimethyl-silane; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja030139k

Reference yield:

: 79414-15-6
2-(triphenyl-λ5-phosphine ylide) 2-(trimethylsilyl)ethyl acetate

: 631919-31-8
2(R)-allyl-3(R)-(2(S)-phenyl-[1,3]dioxan-4(S)-yl)-pent-4-enoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / CH₂Cl₂ / 12 h / Heating

2.1: CuI; TMSCl / tetrahydrofuran / 2 h / -78 °C

3.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

3.2: 72 percent / tetrahydrofuran; toluene / 3 h / -78 °C

With copper(l) iodide; chloro-trimethyl-silane; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja030139k